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However, a number of pitfalls in the methodology of these studies (e.g

545,546 Patients with DPN are also at an increased risk of falls due to sensory loss, balance impairment, and muscle weakness

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The immune response in Graves disease is characterized by involvement of both Th2 and Th17 pathways, with interleukin (IL)-4, IL-6, and IL-17 contributing to B-cell activation and antibody production, while defects in immune checkpoints, such as impaired regulatory T-cell activity, promote loss of tolerance [17,18]