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If your reactions cluster around the same quadrant or follow a dose increase, the failure mode is concentrated exposure, not random bad luck

Morano S, Mandosi E, Fallarino M, Gatti A, Tiberti C, Sensi M, et al

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doi: 10.1016/j.str.2015.04.016

These drugs are part of an emerging class of nutrient-stimulated hormone-based therapeutics that act as incretin mimetics, targeting G-proteincoupled receptors such as GLP-1, glucose-dependent insulinotropic polypeptide (GIP), and glucagon, which are crucial in body fat and energy balance regulation