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GLP-1 receptor agonism is the mechanism semaglutide uses alone

The retatrutide availability timeline depends on ongoing clinical trials and regulatory review: Current status: Multiple phase 3 trials (TRIUMPH program) ongoing Phase 3 primary completion: Expected through mid-year NDA submission: Eli Lilly expected to submit to FDA in late future FDA review period: Approximately 10 months after submission Estimated approval: Potentially late next year at earliest Commercial launch: Could follow shortly after approval It is important to note that Eli Lilly has not announced an official filing timeline

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Impure or degraded product will not produce clinical trial-level results regardless of dose or protocol

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It is unclear whether the effects on weight are sufficient, by themselves, to enable fibrosis regression