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Discovery of a first-in-class receptor interacting protein 1 (RIP1) kinase specific clinical candidate (GSK2982772) for the treatment of inflammatory diseases

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(2025), showed tirzepatide produced a 10.9% reduction in lean mass, though the lean-to-fat loss ratio was more favorable at roughly 25% lean and 75% fat

10.1006/frne.1996.0146 236 RoyA.PandeyS