This does not establish a human appetite or weight-loss effect
The team focused on results from 308 participants who had lost at least 10% of their body weight by the end of the initial 36-week period before switching to the placebo, finding that one year after stopping tirzepatide, 82% of these participants had regained 25% or more of their initial weight reduction
The relatively low discontinuation rate despite side effects affecting 39-44% of users underscores an important point: most adverse events are tolerable and manageable, not severe enough to warrant stopping therapy
PubMed / PMC peer-reviewed research
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