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Contraindications: Uncontrolled hypertension Cardiovascular disease Concurrent use with naltrexone The discontinuation rate in clinical trials was approximately 8.1%, primarily due to nausea

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Evaluation of mtROS with MitoSOX staining 42 indicated that B6 MZB generate more mtROS compared to FoB (Fig

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It further promotes cognitive impairment by inhibiting Rho kinase dependent phosphorylation of endothelial nitric oxide synthase and reducing the production of nitric oxide in brain endothelial cells (Faraco et al., 2018)