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1050 Ivosidenib is being tested in trials for combination therapies with other cancer drugs, including a phase III trial with azacitidine (NCT 03173248), a phase I trial with cytarabine and fludarabine (NCT 04250051), and a phase I/II trial with venetoclax (NCT 03471260)

Mar 2017;156(3):543-548

There are no known serious adverse effects at physiologically relevant doses

Typical progression: Week 12 Improved energy levels Week 34 Better endurance Week 6+ Gradual fat loss Studies indicate modest fat loss (~1 kg over time) when combined with exercise

Another phase III, randomized, open-label, non-inferiority, head-to-head trial, AWARD-6, evaluated dulaglutide (1.5 mg) versus liraglutide (1.8 mg) in patients with T2DM

Phenoxyethanol, a synthetic compound commonly used as a preservative in personal care products, helps to maintain their stability and shelf life