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Other risk factors that may increase vulnerability include: Long duration of diabetes (typically more than 10 years) Poor glycaemic control prior to starting GLP-1 therapy (HbA1c significantly above target) Rapid reduction in HbA1c (a drop of more than 2 percentage points [22 mmol/mol] within 36 months) Concurrent hypertension , especially if poorly controlled Diabetic kidney disease (nephropathy), which often correlates with retinopathy severity Previous history of retinal treatment (laser photocoagulation or intravitreal injections) People with type 2 diabetes but no retinopathy appear to have minimal risk of retinopathy progression based on current evidence

Just sort of jump in and I think you're right as a clinician, like it's one thing, listen, we've all experimented in ourselves

Both of these options are not quick fixes and require a long-term commitment, so it is best to have as much information as possible before deciding if either option is right for you

Healthcare providers might prescribe such a high dose to correct a deficiency, but it is too much to take without medical supervision

& Doroudgar, S

Effects of atypical (risperidone) and typical (haloperidol) antipsychotic agents on astroglial functions