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Immediate studies have shown that tVNS can alter the functional connectivity between the parietal and temporal lobes in patients with mild cognitive impairment (MCI) and enhance the activity of multiple brain regions, thereby improving brain function in MCI patients, with the cingulate gyrus possibly being one of the targets regulated by tVNS in MCI (77)

Others require steady low-dose maintenance to avoid regain issues here

Spatially stable mitochondrial compartments fuel local translation during plasticity

(2018) Metformin reverses early cortical network dysfunction and behavior changes in Huntington's disease

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While they have become extremely popular in the last few years, these medications are not for everyone