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Initially focused on metabolism, research showed NNMT elevation with age/weight leads to fat accumulation, inefficiency, and NAD+ loss.[30][31] High NNMT correlates with insulin resistance and obesity in humans

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[Google Scholar] Effects of exogenous superoxide anion and nitric oxide on the scavenging function and electron microscopic appearance of the sinusoidal endothelium in the isolated, perfused rat liver

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