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In studies combining NNMT inhibition with progressive weighted wheel running (an intensive concurrent endurance and resistance exercise protocol), treated mice exhibited sustained enhanced muscle performance suggesting reduced need for recovery between exercise sessions

doi: 10.1002/glia.22480 222 WilliamsG

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In a 2017 endotoxemia model, TB-500 at 100 mcg/kg intraperitoneal injection reduced serum TNF-, IL-1, and IL-6 by 40 to 55% within four hours of LPS challenge