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8.4 Gastrointestinal tract Pathogenic aggregates, p--Syn, fibrillar -Syn (f--Syn), or Lewy pathology have been found in the upper and lower gastrointestinal tracts of PD patients, with -Syn positive rates declining from proximal to distal

Once activated, NLRP3 facilitates caspase-1 activation, which results in the conversion of pro-IL-1 and pro-IL-18 into their active forms, IL-1 and IL-18 [36]

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Age compounds the problem