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In-vivo imaging of bloodbrain barrier permeability using positron emission tomography with 2-amino-[3-11C] isobutyric acid

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Intracellular redox balance is primarily due to cyclic oxidation and reduction of glutathione both in the mitochondria and cytoplasm of the cells

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However, most current studies rely solely on the EAE mouse model and the LPC-induced localized myelin loss model, which do not fully recapitulate the complex pathological features of MS, particularly its heterogeneity, disease progression, and clinical symptoms