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After our mid-twenties, individuals naturally lose about 1% of their collagen per year

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Some evidence also suggests potential benefits for metabolic dysfunction-associated steatotic liver disease (MASLD, formerly known as NAFLD), a common comorbidity in obesity

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Because bone and joint damage occur later in the course of the disease, X-rays may not be very useful in detecting RA in the early stages, although soft tissue swelling around a joint can be seen on a regular X-ray

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