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Tamaki Y, Nakade Y, Yamauchi T, Makino Y, Yokohama S, Okada M,

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Data from PIONEER 1 were not included because oral semaglutide was given as monotherapy [12], PIONEER 2 was excluded because all patients randomised to oral semaglutide or comparator were receiving background metformin (and no other background glucose-lowering medication) [13], and PIONEER 6 was excluded because it was a cardiovascular outcomes trial [14]

& Dixon, R

Since the borders of our cells are made of fats, things that can pass through fats (called fat-soluble ) can easily pass through the cell membranes