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Why Joint Pain May Occur During GLP-1 Treatment Rapid weight loss altering joint biomechanics is the most likely indirect cause of joint pain during GLP-1 treatment, rather than a direct drug effect

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(PubMed) Todd K, Butterworth RF

286 It has also been suggested that GLP-1 has synergistic effects on adipocytes with insulin, as basal and acute insulin-stimulated glucose uptake was enhanced by GLP-1 and exendin-4 in differentiated 3T3-L1 adipocytes

Nkhoma, E