Beyond 12 months, weight loss typically plateaus as your body finds a new metabolic set point with the medication
Obesity and weight-loss trial programs Type 2 diabetes and glycemic-control research MASLD and liver-fat research Weight-related knee osteoarthritis and pain outcomes Comparisons with semaglutide and tirzepatide Evidence What the research shows The strongest single result available as of May 2026 is the TRIUMPH-4 Phase 3 topline, announced by Lilly on December 11, 2025
When these physiological processes become more balanced, many patients notice fewer cravings, improved fullness after meals, and steadier energy throughout the day
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The clearest early signs are lower fasting blood sugar readings and more stable energy throughout the day
Post-Market Surveillance: After approval, the drug is monitored for long-term effects, and additional studies may be required