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In the STEP-1 trial published in The New England Journal of Medicine in 2021, once-weekly subcutaneous semaglutide at 2.4 mg produced a mean placebo-adjusted body weight reduction of 12.4% at 68 weeks in adults with overweight or obesity (Wilding et al., NEJM, 2021)

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Some might need up to 4,000 IU, especially during periods with little sun exposure 1

Their upregulation may have potential benefits in mood and stress management [3, 4, 5]

This half-life permits once-weekly dosing in approved formulations