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The triple agonist mechanism is fully engaged

Simultaneously, it is clear that there are significant differences in clinical evidence, efficacy, safety, target population, and cost in these studies

Sikiric P, Boban Blagai A, Strbe S, Beketic Oreskovic L, Oreskovic I, et al

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Since PD patients are frequently on multiple therapies, it will be important for future studies to determine the independent effect of these therapies on the gut microbiome and their potential roles in the progression and management of the disease

The proposed mechanism involves accumulated effect over the course rather than peak concentrations