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Studies have demonstrated that donepezil attenuates left ventricular dysfunction by reducing oxidative stress, inflammation, mitochondrial damage, and multiple forms of programmed cell death, including apoptosis, necroptosis, and pyroptosis [177]

However, gastrointestinal side effects and loss of lean mass are notable concerns (5, 10, 17, 18)

In the Wnt pathway, the key step of the Wnt pathway is the binding of the Wnt protein to the Frizzled receptor, and the nuclear redox protein (NRX) blocks Disheveled (DVL) and plays a negative regulatory role in the Wnt pathway (Yu et al., 2021)

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