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Additionally, the researchers aimed to explore the relationship between whole-blood serotonin levels, caffeine consumption, and the frequency of sleep and mood disorders

Fullerton JN, Segre E, De Maeyer RP, et al

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While HSPA5 upregulation can enhance GPX4 activity and inhibit lipid peroxidation, experimental disruption of this pathway (e.g., via siRNA) blocks DHAs protective effect, allowing its inherent ROS-generating capacity to prevail, ultimately inducing ferroptosis [73]