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Secondary outcomes included emergency department (ED) visits, hospitalizations, and all-cause mortality

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ER stress triggers three branch pathways of the UPR, involving activation of transcription factor 6 (ATF6) (Shen et al., 2005), IRE1 (Chen and Brandizzi, 2013), and PERK (Figure 1)

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1 Another 68 week study on once weekly semaglutide injections found that adults with obesity and without diabetes had a mean weight loss of 14.9%, with a third of patients achieving a loss of at least 20% of baseline weight a result approaching that reported 1 to 3 years after bariatric surgery

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