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Combining aggressive time restriction with a medicine that already substantially reduces intake tends to produce poor nutrition and fatigue rather than better results
Maximal weight loss was achieved at year 3 with a mean weight of 96.627.4 kg (2.7% loss of baseline body weight) before rebounding and rising to 100.827.0 kg at year 5
Nat Commun 12(1):5086, 2021
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This suggests the two medication classes operate independently in most patients
Detailed procedural data, including BOTOX dose, injection technique, and baseline bladder capacity, were inconsistently recorded and could impact both efficacy and adverse event rates
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