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That means three things in practice
Notably, in erythroid cells, caspase-3 activation does not guarantee apoptosis execution, since the transcriptional factor GATA-1 essential for erythropoiesis is protected from caspase-3 by HSP70 (heat shock protein 70)
Whether such a POMC effect contributes to the increased mRNA of the steroidogenic enzymes that we found in the septic mice, and thus to the elevated plasma CORT while ACTH is not increased and while the adrenocortical structure and cholesterol ester storage was compromised, remains to be investigated
The mechanism of action may be associated with the reduction of pulmonary oxidative stress levels [94]
For all dosage references, see the peptide dosage chart