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However, the lack of human clinical trials means long-term safety in people remains unknown
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Subcutaneous injection remains the preferred administration route for systemic effects, providing 90-95% bioavailability
They are inactive and require conversion to the native forms, and are not nearly as effective
The time it takes to notice effects can vary depending on the form and dosage
Wegovy pill demonstrated greater weight loss than orforglipron and lower odds of stopping medication due to side effects in a new indirect comparison to be presented at Obesity Medicine Association 2026
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