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Some studies show a small increase in resting metabolic rate, possibly mediated by improved insulin sensitivity and reduced lipotoxicity in tissues
The long-standing use of this drug in diabetes management has led to a lot of clinical data and trust from healthcare professionals, who often prescribe it as a go-to therapy
Besides having a substantial regenerative effect on distressed mucosal barriers, it also acts as a major source of energy for proliferation and differentiation of intestinal epithelial cells
At baseline, mean age and the proportion of subjects with heart failure and prior CV events were higher, and mean eGFR was lower, in the SUSTAIN 6, PIONEER 5 and PIONEER 6 trials than in the other trials
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