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It acts as an enzyme activator and a constituent of metalloenzymes, being involved in several biological functions: synthesis of urea, bone, cartilage, and connective tissue

These issues reflect Cochrane Librarys recommendation for need for independent evidence, both for the short-term and long-term use of GLP-1s

Common side effects In the SUSTAIN trials, the most frequently reported side effects with semaglutide were: 5 Nausea: 11-20% of participants (compared to 3-8% with placebo) Diarrhoea: 4.5-11% of participants Vomiting: 4-11.5% of participants Constipation: Common, particularly in early weeks These side effects are typically mild to moderate and tend to improve as your body adjusts to the medication

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