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Significantly, this resulted in BRAF inhibitor resistance in V600E BRAF melanoma cells (Pan et al, 2016), demonstrating the important link between tumour metabolism and epigenetic changes

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Li C et al (2019) Use of isotretinoin and risk of depression in patients with acne: a systematic review and meta-analysis

Overall, sleep apnea increased by 34%, from 0.8% in 2020 to 1.1% in 2024

PMID: 34324435