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By inactivating ERK signaling, silencing of aldoketo reductase family 1 member C3 (AKR1C3) is reported to inhibit autophagy-dependent glycolysis in TC [273]

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[1] Natural NAD+ levels decline progressively with age

doi: 10.1016/j.scitotenv.2023.167043 12 GuanZ.JinX.GuanZ.LiuS.TaoK.LuoL

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For example, chronic alcohol feeding in diethylnitrosamine (DEN)-induced HCC mice leads to reduced antitumor CD8+ T cells and an increase in tumor-associated macrophages (TAMs), which tend to polarize toward the M2 phenotype after alcohol exposure (89)