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Among the upregulated genes are those encoding DNA repair enzymes (BRCA1, ATM), extracellular matrix proteins (COL1A1, COL3A1, ELN) and antioxidant enzymes (SOD1, SOD2, GPX)

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Thus, it appeared that the serum contained antibodies to a constituent of the human thyroid and that these antibodies might be responsible for the disease process

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There have been substantial evidences that metformin has a regulatory effect on the gut microbiota (Zhang et al., 2015