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The identification of reduced opioid responsiveness in ex vivo preparations derived from tolerant animals, together with seminal studies demonstrating reductions in opioid sensitivity in cultured cells, led to the interest in opioid tolerance as a cell biologic problem

Another study reported that the inhibition of lncRNA ZFAS1 upregulated cardiac GPX4 and terminated the ferroptosis process and oxidative insult in DCM mice [95]

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Principales caractersticas y efectos: Inhibe la sntesis de melanina, neutraliza los radicales libres, mejora la renovacin celular, desintoxicante