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It has been widely referenced in research involving biological signaling processes, structural pathway interaction, and system-level response mechanisms

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IGF-I binds to three receptors, and the binding to IGFIR promotes cell proliferation, survival, differentiation, and migration

After several rounds of heterogeneous refinement, 80,325 particles were used for subsequent NU-refinement, resulting in a 3.70 resolution of the ATD 3D reconstruction