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It typically acts as a comparatively weak diuretic, when administered alone, but has synergistic effects when combined with other diuretics

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Assessment report Article 53 procedure for GLP-1-based therapies

Another comprehensive review found that glutathione synthesis becomes severely diminished in patients with uncontrolled diabetes, yet can be restored through dietary supplementation

If laboratory testing confirms low B12 levels, supplementation may be recommended

In SURMOUNT-1 the 15 mg arm averaged 22.5% body weight loss at 72 weeks, only modestly higher than the 10 mg arm at 21.4%