They dry the skin and can shift pH in ways that destabilize copper peptides
9:e104433 10.1371/journal.pone.0104433 [DOI] [PMC free article] [PubMed] [Google Scholar] 4.Burd I, Balakrishnan B, Kannan, S
Metabolism 51 (10), 13701374
Solutions: Extend trial to 6 months before concluding inefficacy (some benefits take longer), increase dosing within safe ranges if using lower end, switch peptides (try Cerebrolysin if using BPC-157, or vice versa), add comprehensive eye exam to rule out progression versus peptide failure, consider peptides preventing worsening rather than producing improvement, discontinue if truly no benefit after 6 months rigorous trial
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