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Starting Dose (Cagrilintide Starting Dose): In monotherapy trials, the initial dose is typically the lowest level in the escalation schedule, designed to assess tolerability
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In their separate Phase 2 trials, retatrutide monotherapy showed larger weight loss (~24.2% at 48 weeks, 12 mg) than standalone cagrilintide (~10.8% at 26 weeks, 4.5 mg), and indirect network meta-analyses rank retatrutide highly
