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For instance, a study reported that the NF-B signaling pathway is activated in noise-exposed cochleae to protect against inducible nitric oxide synthase-triggered oxidative stress and apoptosis (Tamura et al., 2016)

Its catalytic site is located in a small five amino acid region localized toward the C-terminal end and centered around a serine positioned as amino acid number 630 (25, 34)

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