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A review by Thornton (2013) in Dermato-Endocrinology cited that type I and III skin collagen is thought to decrease by as much as 30% in the first five years after menopause, paralleling the reduction in bone mass observed in the same period (PMC3772914)

That is not the maximum concentration that is possible

It is recommended to consult a doctor or pharmacist before taking it

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Whether such changes represent a physiological adaptation to overall weight reduction or pose a risk for functional decline remains an unresolved issue [13, 14]

2.4.2 Amino acid analysis Amino acids were analysed using the ChromSystems MassChrom Amino Acid Analysis kit following the manufacturers instructions, which facilitates the quantification of 52 amino acids and creatinine in urine