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It would be interesting to investigate a more extensive study population to assess the potential beneficial effects of CRWP in female children with ASD, as the manifestations of ASD can differ between males and females ( Conclusion In conclusion, this study demonstrated that nutritional intervention with CRWP effectively improved glutathione levels in children with ASD, ameliorated some behavioral domains impacted in ASD and was well-tolerated

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It might also be important to investigate the role of treatment with other forms of folate besides folinic acid, but it might also be wise to concentrate research on one particular form of folate for the time being so as to optimize the generalizability of research studies in order to have a more solid understanding of the role of folate metabolism in ASD