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The benefit of the GLP-1 agonists may be from the reduction of adiposity, or non-adiposity related

Antonopoulos AS , Margaritis M , Lee R , Channon K , Antoniades C

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The appetite-suppressing effect of semaglutide and constipation stem from the same mechanismslowed gastric emptyingbut many patients achieve excellent results with minimal digestive disruption

Bent AH, Parseghian C, Morris VK, Kee BK, Huey RW, Morelli MP, Shen JP, Jernigan K, Fernandez A, Harrison C, Horodecky K, Dasari A, Alfaro K, Aziz K, Kell RJ, Kopetz S

What is Chronic Inflammatory Response Syndrome (CIRS)