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Functionally it is a straightforward GHRH-receptor agonist: it binds the receptor on pituitary somatotrophs and stimulates endogenous, pulsatile GH release, which secondarily raises IGF-1

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[25] Mechanism of action [edit] Dulaglutide binds to glucagon-like peptide 1 receptors, slowing gastric emptying and increasing insulin secretion by pancreatic Beta cells