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In trials to assess semaglutides effectiveness for reducing the risk of major cardiovascular events in adults, increases in total bilirubin greater than or equal to 3 times the upper limit of normal were seen in .3% of people taking Wegovy versus .2% of people taking the placebo

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The study authors concluded their main finding to be that the prescribed use of semaglutide is associated with an increased risk for developing NAION

M., Tsai-Morris, C.-H

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