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She develops intrahepatic cholestasis (0.4-10% of pregnancies), which has been associated with fatal outcomes from therapeutic acetaminophen doses

In the CY 2024 OPPS/ASC final rule with comment period (88 FR 81594), we codified the OPPS program payment and cost as required by section 1833(t)(8)(F) of the Act by adding a new paragraph (e) to 419.41, which cross-references the regulations adopted in the CY 2024 PFS final rule ( 410.152(m) and 489.30(b)(6))

doi: 10.1097/MD.0000000000038229 233 KimSJJungCWAnhNHKimSWParkSKwonSWet al

Drug Metab Dispos 18(5):765770 Roberts SA, Price VF, Jollow DJ (1990) Acetaminophen structure-toxicity studies: in vivo covalent binding of a nonhepatotoxic analog, 3-hydroxyacetanilide

A subset of prescribers combine oral and subcutaneous administration simultaneously (e.g., 250 mcg oral in the morning plus 250 mcg subcutaneous in the evening)

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