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In mice fed Se deficient diets, testicular atrophy, reduced diameter of the seminiferous tubules, osseous metaplasia, and reduced spermatogenic activity were observed: no mitotic activity in spermatogonia, reduced the number of spermatogenic cell lines (including stem cells, pachytene spermatocytes, spermatids, and maturing sperms), and higher rates of abnormal morphology of sperm were found without difference in chromosomal abnormalities in spermatocytes (85, 100)

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Skin Necrosis or Tissue Damage : If the injection is too close to the skin surface or excessive volume is used, localized tissue injury may occur

Nucl Recept Signal 2007;5:e012.PubMedPMC 91

Napolitano G, Fasciolo G, Di Meo S, Venditti P, Vitamin E