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This interaction appears to initiate a series of intracellular signaling cascades

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Similarly, a meta-analysis of nine observational studies in older adults found low serum vitamin B 12 concentration to be associated with increased risk for depression, with significant association only in women (100)

Pernicious anemia refers to a vitamin B12 deficiency caused by autoantibodies that interfere with vitamin B12 absorption by targeting intrinsic factor (IF), gastric parietal cells, or both