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Chou CC, Lee KH, Lai IL, Wang D, Mo X, Kulp SK, Shapiro CL, Chen CS

The honest summary: Retatrutide probably does produce modestly greater weight loss than tirzepatide at maximum doses, potentially in the range of 36 percentage points of body weight

Topiramate is an antiepileptic drug, and this class carries an FDA warning about increased risk of suicidal thoughts and behavior

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These neurobiological findings indicate central engagement of mesolimbic circuits relevant to addiction and support a potential role for GLP-1R agonists in modulating incentive salience and dopaminergic tone, even in the absence of overt clinical behavioral differences [79]