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doi: 10.1111/j.1365-2796.2011.02428.x 16 LimE-JSonC-G

Treatment with pioglitazone while breastfeeding should only happen under close monitoring from your diabetes healthcare professional when an alternative is not suitable

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10.1056/NEJMra1106180 N Engl J Med

In patients with T2DM, where islet neogenesis and -cell replication are normal, increased apoptosis is the main cause of the decrease in their -cell numbers, so preventing -cell apoptosis may become an effective means of treating T2DM ( GLP-1 has a beneficial effect on -cell function by promoting -cell proliferation and neogenesis and reducing apoptosis (Zheng et al., 2022)