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The underlying processes are complex and only partly understood

Dose Escalation After the initial phase, doses are generally increased every 4 weeks as tolerated: Weeks 58 : 0.5 mg once weekly Weeks 912 : 1.0 mg once weekly Weeks 13+ : 1.7 to 2.4 mg once weekly (as the target maintenance dose) Gradual dose escalation of semaglutide is necessary to improve tolerability and limit GI side effects. Davies et al., The Lancet Ideal Cycle Length Most semaglutide cycles run for 1624 weeks depending on goals, response, and budget

But they continue to be critical even later

Prednisone's effect is dose-dependent and continuous

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However: Rapid weight loss changes nutritional requirements