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Peripheral administration of LIRA leads to its localisation in circumventricular organs and the hypothalamic arcuate nucleus, where it promotes the activation of anorexigenic pathways and the inhibition of orexigenic ones

SIRT1 and SIRT3 in particular have been identified as key mediators of the beneficial effects of caloric restriction, the only intervention consistently shown to extend lifespan across species

Intrinsic protein disorder and protein modifications in the processing of biological signals

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Avoid energy drinks with excessive sugar, as they worsen blood sugar instability