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However, GSIS was decreased following oral but not intraperitoneal glucose administration in DIRKO compared to mice with just one of these receptors knocked out

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Semaglutide is a pure GLP-1 receptor agonist

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These effects contribute to weight loss that varies by agent and dosetypically ranging from 5-8% with liraglutide 3 mg (Saxenda), up to 15% with semaglutide 2.4 mg (Wegovy), and potentially up to 20% with higher doses of tirzepatide (Zepbound)

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