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These findings provide a mechanistic foundation for developing RNA-based therapeutic interventions (Bao et al., 2020

Most gastrointestinal symptoms peak during dose escalation and may diminish over time as tolerance develops

132,133 Another postulated beneficial effect of KD is related to longevity

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The comparison below summarizes when each option is typically appropriate

The C-terminal of PLC- isoforms shows some differences, and the PLC- subfamily has a unique 450-amino acid long C-terminal extension, but the significance of this difference is unknown